I take Andrographis at the very first signs of colds and flu. It never fails to reduce my symptoms and cut the duration of my illness.
Andrographis paniculata is a plant native to South and Southeast Asia, used for centuries in traditional Ayurvedic and Chinese medicine. Its bitter leaves and stems contain several bioactive compounds — especially andrographolide — believed to have medicinal properties. Today it’s commonly sold as a dietary supplement, often standardized for andrographolide content. (Natural Healthy Concepts)
Potential Benefits
1. Respiratory Infections
(Colds & Flu)
This is the area with the
most clinical research. Andrographis extracts have been shown to reduce
symptoms of acute respiratory infections — including cough, sore throat, and
congestion — and may slightly shorten the duration of illness compared with placebo.
Systematic reviews and meta-analyses of randomized trials support modest
benefits, though many studies vary in quality. (PubMed)
2. Immune Support
Some research suggests
andrographis may support immune function, potentially through anti-inflammatory
and antioxidant actions attributed to andrographolide and other constituents.
These effects are part of why it’s marketed for immune-health support, though
human evidence beyond respiratory symptoms is limited. (Natural Healthy Concepts)
3. Anti-Inflammatory
Effects
Test-tube and cell studies
indicate that andrographolide may suppress inflammatory mediators like TNF-α,
which could theoretically explain some of its traditional uses. (PubMed)
4. Other Areas (Emerging
or Preliminary Research)
- Osteoarthritis: A clinical study saw improvements in knee pain and function with
a standardized andrographis extract versus placebo. (Drugs.com)
- Ulcerative Colitis: Older trials showed some symptom improvement in
mild to moderate disease, but results are preliminary. (Healthline)
- Cardiovascular & Metabolic Effects: Early research suggests potential effects on
lipid metabolism and endothelial function, but these require much stronger
evidence before clinical recommendations. (Well
Being Journal)
It’s important to emphasize
that outside of respiratory symptoms and a few specific conditions, the
evidence remains preliminary.
Clinical Studies &
Quality of Evidence
There are clinical trials
on Andrographis — especially for upper respiratory infections. For example:
- A controlled study found standardized
Andrographis extract reduced both symptom severity and duration in people
with common colds compared to placebo. (PubMed)
- Large reviews (meta-analyses) have pooled
multiple trials and concluded that Andrographis appears more effective
than placebo for symptom relief and slightly shortening recovery time.
However, many of these studies have limitations in design, size, and
reporting quality. (PubMed)
In summary, clinical evidence
supports its use for mild cold/flu symptoms, but well-designed trials are still
needed for most other health claims.
Safety and Side Effects
Herbal preparations of Andrographis
paniculata are generally well-tolerated in most people at typical doses.
Mild side effects may include gastrointestinal discomfort (nausea, diarrhea)
and occasional headaches. Serious allergic reactions are rare but possible. (PubMed)
As with any supplement, it’s
wise to talk with a healthcare provider before starting — especially if you’re
pregnant, breastfeeding, taking medications, or have chronic health conditions.
Bottom Line
- What it is: A traditional medicinal herb with active compounds like
andrographolide.
- Primary benefit: Evidence supports modest relief of respiratory
infection symptoms (colds/flu).
- Other uses: Some studies suggest anti-inflammatory, joint-support, and
digestive benefits, but more high-quality research is needed.
- Safety:
Generally safe but not risk-free; allergic reactions and mild digestive
side effects can occur.








